A core challenge in biology is understanding how processes in the body, such as cellular development and regeneration, unfold ...

Knowing the location of a gene within intact tissue or a single cell allows scientists to unlock unknown cellular functions. This information is often lost in most genetic sequencing techniques, but ...

Biological systems are inherently three-dimensional—tissues form intricate layers, networks, and architectures where cells interact in ways that extend far beyond a flat plane. To capture the true ...

A novel spatial transcriptomics atlas developed by Northwestern Medicine scientists may improve the understanding of niche ...

Inflammatory bowel disease (IBD) is an umbrella term for Crohn's disease and ulcerative colitis, which both involve chronic inflammation ... | Cell And Molecular Biology ...

This illustration summarizes how integrated spatial transcriptomics, single-cell transcriptomics, single-cell epigenomics, and spatial epigenomics enable multi-dimensional profiling of the tumor ...

Single-cell RNA sequencing has transformed biology by showing which genes are active in individual cells. However, this approach requires cells to be removed from their natural environment, erasing ...

Spatial and single-cell analyses of human donor pancreata showed that PanIN epithelial cells gradually acquire cancer-like molecular features, while their surrounding stromal and immune environment ...

Using spatial multi-omics, researchers identified shifting macrophage populations in MASLD progression, identifying markers to aid patient stratification in clinical trials.